Invasions and Inversions: Representations of Otherness in the Writings of Bram Stoker

Bram Stoker has long been defined by a single text: Dracula. The elements that drove this unparalleled success – foremost among them a perverse interest in ‘otherness’ – frequently manifest in Stoker’s other works, however. Building on the exemplary writings of Stokerian scholars such as William Hughes and David Glover, this study aims to expand its literary horizons, providing a comprehensive look at depictions of otherness across the author’s entire literary canon. This study finds its focal point in the twin faces of invasion and inversion. Within these terms are encapsulated many meanings: the balance of what is ‘out there’ and what is ‘in here,’ of what is trying to get out and what is trying to get in, of that which is on the surface and that which resides beneath. This thesis draws on all manner of Stoker’s work – novels, short stories, and non-fiction work – to map the author’s perception of otherness. And although the study may be anchored by region, the ‘representations of otherness’ extend far beyond geographical concerns: the ‘foreignness’ that so unsettles Stoker is far-reaching, often being tied up in wider questions of gendered, religious, or sexual otherness. This thesis forges a connection between a preoccupation with otherness and the author’s own complex national identity, identifying a distinct literary persona created as a form of camouflage. Stoker’s hegemonic performance allows him to engage with questions of otherness from a place of assumed safety, ostensibly identifying as a member of a perceived elite – yet it is doomed to remain incomplete. At heart, Stoker knows the divisions he propagates to be false constructs; after all, he has manipulated them himself in the creation of his authorial persona. For Stoker the true horror exists in his interior: not what is ‘out there’ trying to get in, but what is ‘in here’ trying to get out

Moving spaces: choreography, metaphor and meaning

Space is as integral to choreography as time, energy, and the body in motion. In this dissertation, Moving Spaces: Choreography, Metaphor, and Meaning, I ask how choreographic space acquires meaning, consider the kinds of meanings it conveys, and discover where those meanings are located within a dance. I explore, then, the ways our perceptions of space are influenced by culture, personal experience, and biology, and question to what degree our responses are universal or unique. I reflect on and analyse a selection of my choreographic work, view the work of other choreographers, and draw on the writings of scholars in dance and other disciplines to describe and think through my dances. I investigate these writers’ views on dance, space, meaning, and the body in motion and link them to my practical research. I see the views and theories of four scholars as particularly significant: Gaston Bachelard’s insights about imagination and metaphor, and how art reflects our sense of intimate space; Rudolf Laban’s notions of spatial geometry and the interconnections between space, time, and force; Ivar Hagendoorn’s discussions of neurological research, which offer insights into both the creation and perception of space in dance; and, Yi Fu Tuan’s illuminating ideas about the cultural influences on our experiences of space and place. I consider the meaning of space in my dances, and examine how these works articulate my own cultural and personal experiences of growing up and living in New York City and as an expatriate in Hong Kong. Through this close reading of my choreography, and with an understanding that there are no universal terms for viewing space, I suggest the importance of taking into account a multifaceted approach to understanding space in dance, including the reflections and insights of artists

Perinatal mental health education for midwives in Victoria

Perinatal mental health issues affect women and their families world-wide. Midwives can make a difference to women and families lives with early and prompt detection of perinatal mental health issues

A population-based audit of ethnicity and breast cancer risk in one general practice catchment area in North London, UK: implications for practice

<p>Abstract</p> <p>Objectives</p> <p>To conduct a pilot population-based study within a general practice catchment area to determine whether the incidence of breast cancer was increased in the Ashkenazi population.</p> <p>Design</p> <p>Population-based cohort study.</p> <p>Setting</p> <p>A single general practice catchment area in North London.</p> <p>Participants</p> <p>1947 women over the age of 16 who responded to a questionnaire about ethnicity and breast cancer.</p> <p>Main outcome measures</p> <p>Incidence of breast cancer, ethnicity.</p> <p>Results</p> <p>This study showed a 1.5-fold (95% CI 0.93–2.39) increase in breast cancer risk in the Ashkenazim compared with the non-Ashkenazi white population. The increased incidence was for both premenopausal and postmenopausal breast cancer (expected incidence pre:post is 1:4 whereas in the Ashkenazim it was 1:1; 51 and 52% of cases respectively). This increase was not shown in the Sephardim. Asians had a reduction in incidence (OR = 0.44; 95% CI 0.10–1.89). Results were adjusted for other risk factors for breast cancer.</p> <p>Conclusion</p> <p>This study showed a 1.5-fold increase in breast cancer rates in Ashkenazim compared with the non-Jewish white population when adjusted for age (i.e. corrections were made to allow comparison of age groups) and this is not observed in the Sephardic population. The proportion of premenopausal breast cancer was just over double that of the general population. This is the first general practice population-based study in the UK to address this issue and has implications for general practitioners who care for patients from the Ashkenazi community.</p

The International Limits and Population at Risk of Plasmodium vivax Transmission in 2009

Growing evidence shows that Plasmodium vivax malaria is clinically less benign than has been commonly believed. In addition, it is the most widely distributed species of human malaria and is likely to cause more illness in certain regions than the more extensively studied P. falciparum malaria. Understanding where P. vivax transmission exists and measuring the number of people who live at risk of infection is a fundamental first step to estimating the global disease toll. The aim of this paper is to generate a reliable map of the worldwide distribution of this parasite and to provide an estimate of how many people are exposed to probable infection. A geographical information system was used to map data on the presence of P. vivax infection and spatial information on climatic conditions that impede transmission (low ambient temperature and extremely arid environments) in order to delineate areas where transmission was unlikely to take place. This map was combined with population distribution data to estimate how many people live in these areas and are, therefore, exposed to risk of infection by P. vivax malaria. The results show that 2.85 billion people were exposed to some level of risk of transmission in 2009

The 3D-HST Survey: <i>Hubble Space Telescope</i> WFC3/G141 Grism Spectra, Redshifts, and Emission Line Measurements for ~ 100,000 Galaxies

We present reduced data and data products from the 3D-HST survey, a 248-orbit $HST$ Treasury program. The survey obtained WFC3 G141 grism spectroscopy in four of the five CANDELS fields: AEGIS, COSMOS, GOODS-S, and UDS, along with WFC3 $H_{140}$ imaging, parallel ACS G800L spectroscopy, and parallel $I_{814}$ imaging. In a previous paper, we presented photometric catalogs in these four fields and in GOODS-N, the fifth CANDELS field. Here we describe and present the WFC3 G141 spectroscopic data, again augmented with data from GO-1600 in GOODS-N (PI: B. Weiner). We developed software to automatically and optimally extract interlaced two-dimensional (2D) and one-dimensional (1D) spectra for all objects in the Skelton et al. (2014) photometric catalogs. The 2D spectra and the multi-band photometry were fit simultaneously to determine redshifts and emission line strengths, taking the morphology of the galaxies explicitly into account. The resulting catalog has redshifts and line strengths (where available) for 22,548 unique objects down to ${{JH}}_{\mathrm{IR}}\leq 24$ (79,609 unique objects down to ${{JH}}_{\mathrm{IR}}\leq 26$). Of these, 5459 galaxies are at $z > 1.5$ and 9621 are at $0.7< z< 1.5$, where Hα falls in the G141 wavelength coverage. The typical redshift error for ${{JH}}_{\mathrm{IR}}\leq 24$ galaxies is ${\sigma }_{z}\approx 0.003\times (1+z)$, i.e., one native WFC3 pixel. The $3\sigma$ limit for emission line fluxes of point sources is $2.1\times {10}^{-17}$ erg $s^{-1} cm^{-2}$. All 2D and 1D spectra, as well as redshifts, line fluxes, and other derived parameters, are publicly available

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans

Alcohol is a potent pharmacological agent when consumed acutely at sufficient quantities and repeated overuse can lead to addiction and deleterious effects on health. Alcohol is thought to modulate neuronal function through low-affinity interactions with proteins, in particular with membrane channels and receptors. Paradoxically, alcohol acts as both a stimulant and a sedative. The exact molecular mechanisms for the acute effects of ethanol on neurons, as either a stimulant or a sedative, however remain unclear. We investigated the role that the heat shock transcription factor HSF-1 played in determining a stimulatory phenotype of Caenorhabditis elegans in response to physiologically relevant concentrations of ethanol (17 mM; 0.1% v/v). Using genetic techniques, we demonstrate that either RNA interference of hsf-1 or use of an hsf-1(sy441) mutant lacked the enhancement of locomotion in response to acute ethanol exposure evident in wild-type animals. We identify that the requirement for HSF-1 in this phenotype was IL2 neuron-specific and required the downstream expression of the α-crystallin ortholog HSP-16.48. Using a combination of pharmacology, optogenetics, and phenotypic analyses we determine that ethanol activates a Gαs-cAMP-protein kinase A signaling pathway in IL2 neurons to stimulate nematode locomotion. We further implicate the phosphorylation of a specific serine residue (Ser322) on the synaptic protein UNC-18 as an end point for the Gαs-dependent signaling pathway. These findings establish and characterize a distinct neurosensory cell signaling pathway that determines the stimulatory action of ethanol and identifies HSP-16.48 and HSF-1 as novel regulators of this pathway